Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma

Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumor in humans. Systemic immunity against gene therapy vectors has been shown to hamper therapeutic efficacy; however, helper-dependent high-capacity adenovirus (HC-Ad) vectors elicit sustained transgene expression,...

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Hauptverfasser: Muhammad, AKMG, Puntel, M, Candolfi, M, Salem, A, Yagiz, K, Farrokhi, C, Kroeger, KM, Xiong, W, Curtin, JF, Liu, C, Lawrence, K, Bondale, NS, Lerner, J, Baker, GJ, Foulad, D, Pechnick, RN, Palmer, D, Ng, P, Lowenstein, PR, Castro, MG
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908190/
https://ncbi.nlm.nih.gov/pubmed/20164833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2009.260
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