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Safety Profile, Efficacy, and Biodistribution of a Bicistronic High-Capacity Adenovirus Vector Encoding a Combined Immunostimulation and Cytotoxic Gene Therapy as a Prelude to a Phase I Clinical Trial for Glioblastoma
Adenoviral vectors (Ads) are promising gene delivery vehicles due to their high transduction efficiency; however, their clinical usefulness has been hampered by their immunogenicity and the presence of anti-Ad immunity in humans. We reported the efficacy of a gene therapy approach for glioma consist...
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Main Authors: | , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3641940/ https://ncbi.nlm.nih.gov/pubmed/23403069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.02.001 |
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