Safety Profile, Efficacy, and Biodistribution of a Bicistronic High-Capacity Adenovirus Vector Encoding a Combined Immunostimulation and Cytotoxic Gene Therapy as a Prelude to a Phase I Clinical Trial for Glioblastoma

Adenoviral vectors (Ads) are promising gene delivery vehicles due to their high transduction efficiency; however, their clinical usefulness has been hampered by their immunogenicity and the presence of anti-Ad immunity in humans. We reported the efficacy of a gene therapy approach for glioma consist...

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Hauptverfasser: Puntel, Mariana, Muhammad, AKM Ghulam, Farrokhi, Catherine, VanderVeen, Nathan, Paran, Christopher, Appelhans, Ashley, Kroeger, Kurt M., Salem, Alireza, Lacayo, Liliana, Pechnick, Robert N., Kelson, Kyle R, Kaur, Sukhpreet, Kennedy, Sean, Palmer, Donna, Ng, Philip, Liu, Chunyan, Krasinkiewicz, Johnny, Lowenstein, Pedro R., Castro, Maria G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641940/
https://ncbi.nlm.nih.gov/pubmed/23403069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.02.001
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