NSAID Sulindac and Its Analogs Bind RXRα and Inhibit RXRα-dependent AKT Signaling

Non-steroidal anti-inflammatory drugs (NSAIDs) exert their anti-cancer effects through cyclooxygenase-2 (COX-2)-dependent and -independent mechanisms. Here we report that Sulindac, an NSAID, induces apoptosis by binding to retinoid X receptor-α (RXRα). We identified an N-terminally-truncated RXRα (t...

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Main Authors: Zhou, Hu, Liu, Wen, Su, Ying, Wei, Zhen, Liu, Jie, Kolluri, Siva Kumar, Wu, Hua, Cao, Yu, Chen, Jiebo, Wu, Yin, Yan, Tingdong, Cao, Xihua, Gao, Weiwei, Molotkov, Andrei, Jiang, Fuquan, Li, Wen-Gang, Lin, Bingzhen, Zhang, Hai-Ping, Yu, Jinghua, Luo, Shi-Peng, Zeng, Jin-zhang, Duester, Gregg, Huang, Pei-Qiang, Zhang, Xiao-kun
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907921/
https://ncbi.nlm.nih.gov/pubmed/20541701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.04.023
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