An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca(2+) sensing

Ca(2+)-activated BK channels modulate neuronal activities including spike frequency adaptation and synaptic transmission. Previous studies found that Ca(2+) binding sites and the activation gate are spatially separated in the channel protein, but the mechanism by which Ca(2+) binding opens the gate...

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Hlavní autoři: Yang, Junqiu, Krishnamoorthy, Gayathri, Saxena, Akansha, Zhang, Guohui, Shi, Jingyi, Yang, Huanghe, Delaloye, Kelli, Sept, David, Cui, Jianmin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907746/
https://ncbi.nlm.nih.gov/pubmed/20620873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.05.009
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