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An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca(2+) sensing
Ca(2+)-activated BK channels modulate neuronal activities including spike frequency adaptation and synaptic transmission. Previous studies found that Ca(2+) binding sites and the activation gate are spatially separated in the channel protein, but the mechanism by which Ca(2+) binding opens the gate...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2907746/ https://ncbi.nlm.nih.gov/pubmed/20620873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.05.009 |
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