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α′-Hydroxyenones as Mechanistic Probes and Scope-Expanding Surrogates for α,β-Unsaturated Aldehydes in NHC-Catalyzed Reactions

N-heterocyclic carbene catalyzed reactions of α,β-unsaturated aldehydes and a variety of electrophiles allow the facile preparation of a diverse array of annulation products including tri-substituted cyclopentenes, γ-lactams, and bicyclic β-lactams. The substrate scope of these reactions, however, i...

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Autors principals: Chiang, Pei-Chen, Rommel, Michael, Bode, Jeffrey W.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907655/
https://ncbi.nlm.nih.gov/pubmed/19530737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja902143w
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