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A new drug delivery method of bispecific ligand-directed toxins that reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancer

OBJECTIVE: Biologicals targeting EGFR and IL-13R react with over-expressed markers on cancer cells, but also react with receptor on normal cells. Since we developed novel bispecific ligand directed toxins (BLT) synthesized by cloning EGF and IL-13 on the same molecule with toxin, our objective was t...

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Библиографические подробности
Главные авторы: Oh, Seunguk, Stish, Brad J, Vickers, Selwyn M., Buchsbaum, Donald J., Vallera, Daniel A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907476/
https://ncbi.nlm.nih.gov/pubmed/20182395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0b013e3181cbd908
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