Design and modification of EGF4KDEL 7Mut, a novel bispecific ligand-directed toxin, with decreased immunogenicity and potent anti-mesothelioma activity

BACKGROUND: Potency, immunogenicity, and toxicity are three problems that limit the use of targeted toxins in solid tumour therapy. METHODS: To address potency, we used genetic engineering to develop a novel bispecific ligand-directed toxin (BLT) called EGF4KDEL, a novel recombinant anti-mesotheliom...

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Main Authors: Stish, B J, Oh, S, Chen, H, Dudek, A Z, Kratzke, R A, Vallera, D A
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768099/
https://ncbi.nlm.nih.gov/pubmed/19755995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605297
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