Rational Optimization of a Bispecific Ligand Trap Targeting EGF Receptor Family Ligands

The human EGF receptor (HER) family members cooperate in malignancy. Of these, HER2 does not bind growth factors and HER3 does not encode an active tyrosine kinase. This diversity creates difficultly in creating pan-specific therapeutic HER family inhibitors. We have identified single amino acid cha...

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Main Authors: Jin, Pei, Zhang, Juan, Beryt, Malgorzata, Turin, Lisa, Brdlik, Cathleen, Feng, Ying, Bai, Xiaomei, Liu, Jim, Jorgensen, Brett, Shepard, H. Michael
Format: Artigo
Jezik:Inglês
Izdano: ScholarOne 2009
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592073/
https://ncbi.nlm.nih.gov/pubmed/19048033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2008.00103
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