Rational Optimization of a Bispecific Ligand Trap Targeting EGF Receptor Family Ligands

The human EGF receptor (HER) family members cooperate in malignancy. Of these, HER2 does not bind growth factors and HER3 does not encode an active tyrosine kinase. This diversity creates difficultly in creating pan-specific therapeutic HER family inhibitors. We have identified single amino acid cha...

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Detaylı Bibliyografya
Asıl Yazarlar: Jin, Pei, Zhang, Juan, Beryt, Malgorzata, Turin, Lisa, Brdlik, Cathleen, Feng, Ying, Bai, Xiaomei, Liu, Jim, Jorgensen, Brett, Shepard, H. Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: ScholarOne 2009
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592073/
https://ncbi.nlm.nih.gov/pubmed/19048033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2008.00103
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