SEPSIS INCREASES THE EXPRESSION AND ACTIVITY OF THE TRANSCRIPTION FACTOR FORKHEAD BOX O 1 (FOXO1) IN SKELETAL MUSCLE BY A GLUCOCORTICOID-DEPENDENT MECHANISM

Sepsis-induced muscle wasting has severe clinical consequences, including muscle weakness, need for prolonged ventilatory support and stay in the intensive care unit, and delayed ambulation with risk for pulmonary and thromboembolic complications. Understanding molecular mechanisms regulating loss o...

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Bibliographic Details
Main Authors: Smith, Ira J., Alamdari, Nima, O’Neal, Patrick, Gonnella, Patricia, Aversa, Zaira, Hasselgren, Per-Olof
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907176/
https://ncbi.nlm.nih.gov/pubmed/20079455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2010.01.006
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