Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1β in skeletal muscle

Muscle wasting during sepsis is at least in part regulated by glucocorticoids and is associated with increased transcription of genes encoding the ubiquitin ligases atrogin-1 and muscle-specific RING-finger protein-1 (MuRF1). Recent studies suggest that muscle atrophy caused by denervation is associ...

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Main Authors: Menconi, Michael J., Arany, Zoltan P., Alamdari, Nima, Aversa, Zaira, Gonnella, Patricia, O'Neal, Patrick, Smith, Ira J., Tizio, Steven, Hasselgren, Per-Olof
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957862/
https://ncbi.nlm.nih.gov/pubmed/20647557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00596.2009
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