SEPSIS INCREASES THE EXPRESSION AND ACTIVITY OF THE TRANSCRIPTION FACTOR FORKHEAD BOX O 1 (FOXO1) IN SKELETAL MUSCLE BY A GLUCOCORTICOID-DEPENDENT MECHANISM

Sepsis-induced muscle wasting has severe clinical consequences, including muscle weakness, need for prolonged ventilatory support and stay in the intensive care unit, and delayed ambulation with risk for pulmonary and thromboembolic complications. Understanding molecular mechanisms regulating loss o...

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Detalhes bibliográficos
Main Authors: Smith, Ira J., Alamdari, Nima, O’Neal, Patrick, Gonnella, Patricia, Aversa, Zaira, Hasselgren, Per-Olof
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907176/
https://ncbi.nlm.nih.gov/pubmed/20079455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2010.01.006
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