Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

Obsessive-compulsive disorder (OCD) is a common psychiatric disorder defined by the presence of obsessive thoughts and repetitive compulsive actions, and it often encompasses anxiety and depressive symptoms1,2. Recently, the corticostriatal circuitry has been implicated in the pathogenesis of OCD3,4...

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Hauptverfasser: Shmelkov, Sergey V, Hormigo, Adília, Jing, Deqiang, Proenca, Catia C, Bath, Kevin G, Milde, Till, Shmelkov, Evgeny, Kushner, Jared S, Baljevic, Muhamed, Dincheva, Iva, Murphy, Andrew J, Valenzuela, David M, Gale, Nicholas W, Yancopoulos, George D, Ninan, Ipe, Lee, Francis S, Rafii, Shahin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907076/
https://ncbi.nlm.nih.gov/pubmed/20418887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2125
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