CD133 expression is not restricted to stem cells, and both CD133(+) and CD133(–) metastatic colon cancer cells initiate tumors

Colon cancer stem cells are believed to originate from a rare population of putative CD133(+) intestinal stem cells. Recent publications suggest that a small subset of colon cancer cells expresses CD133, and that only these CD133(+) cancer cells are capable of tumor initiation. However, the precise...

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Main Authors: Shmelkov, Sergey V., Butler, Jason M., Hooper, Andrea T., Hormigo, Adilia, Kushner, Jared, Milde, Till, St. Clair, Ryan, Baljevic, Muhamed, White, Ian, Jin, David K., Chadburn, Amy, Murphy, Andrew J., Valenzuela, David M., Gale, Nicholas W., Thurston, Gavin, Yancopoulos, George D., D’Angelica, Michael, Kemeny, Nancy, Lyden, David, Rafii, Shahin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391278/
https://ncbi.nlm.nih.gov/pubmed/18497886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34401
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