Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

Obsessive-compulsive disorder (OCD) is a common psychiatric disorder defined by the presence of obsessive thoughts and repetitive compulsive actions, and it often encompasses anxiety and depressive symptoms1,2. Recently, the corticostriatal circuitry has been implicated in the pathogenesis of OCD3,4...

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Autores principales: Shmelkov, Sergey V, Hormigo, Adília, Jing, Deqiang, Proenca, Catia C, Bath, Kevin G, Milde, Till, Shmelkov, Evgeny, Kushner, Jared S, Baljevic, Muhamed, Dincheva, Iva, Murphy, Andrew J, Valenzuela, David M, Gale, Nicholas W, Yancopoulos, George D, Ninan, Ipe, Lee, Francis S, Rafii, Shahin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907076/
https://ncbi.nlm.nih.gov/pubmed/20418887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2125
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