KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation

Localized chromatin modifications of histone tails play an important role in regulating gene transcription, and aberration of these processes leads to carcinogenesis. Methylated histone lysine residues, a key player in chromatin remodeling, are demethylated by the JmjC class of enzymes. Here we show...

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Autors principals: Hsia, Datsun A., Tepper, Clifford G., Pochampalli, Mamata R., Hsia, Elaine Y. C., Izumiya, Chie, Huerta, Steve B., Wright, Michael E., Chen, Hong-Wu, Kung, Hsing-Jien, Izumiya, Yoshihiro
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906833/
https://ncbi.nlm.nih.gov/pubmed/20457893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000401107
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