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TARGETING THE DIMERIZATION OF EPIDERMAL GROWTH FACTOR RECEPTORS WITH SMALL-MOLECULE INHIBITORS

The epidermal growth factor (EGF) receptor is a receptor tyrosine kinase involved in the control of cell proliferation. EGF receptor dimerization is a pre-requisite for kinase activation, and is the basis for exploring the feasibility of inhibiting EGF receptor activation by blocking dimer formation...

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Bibliografische gegevens
Hoofdauteurs: Yang, Robert Y. C., Yang, Katherine S., Pike, Linda J., Marshall, Garland R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906783/
https://ncbi.nlm.nih.gov/pubmed/20456371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.00986.x
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