Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice

Total deficiency of complement factor H (CFH) is associated with dense deposit disease (DDD) and atypical haemolytic uraemic syndrome (aHUS). CFH is the major regulator of the alternative pathway of complement activation and its complete deficiency results in uncontrolled C3 activation through this...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Fakhouri, F., de Jorge, E. Goicoechea, Brune, F., Azam, P., Cook, H.T., Pickering, M.C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906702/
https://ncbi.nlm.nih.gov/pubmed/20445496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2010.132
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky