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Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice
Total deficiency of complement factor H (CFH) is associated with dense deposit disease (DDD) and atypical haemolytic uraemic syndrome (aHUS). CFH is the major regulator of the alternative pathway of complement activation and its complete deficiency results in uncontrolled C3 activation through this...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906702/ https://ncbi.nlm.nih.gov/pubmed/20445496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2010.132 |
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