Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice

Total deficiency of complement factor H (CFH) is associated with dense deposit disease (DDD) and atypical haemolytic uraemic syndrome (aHUS). CFH is the major regulator of the alternative pathway of complement activation and its complete deficiency results in uncontrolled C3 activation through this...

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Hauptverfasser: Fakhouri, F., de Jorge, E. Goicoechea, Brune, F., Azam, P., Cook, H.T., Pickering, M.C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906702/
https://ncbi.nlm.nih.gov/pubmed/20445496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2010.132
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