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Temporal Study of Acetaminophen (APAP) and S-Adenosyl-L-methionine (SAMe) Effects on Subcellular Hepatic SAMe Levels and Methionine Adenosyltransferase (MAT) Expression and Activity

Acetaminophen (APAP) is the leading cause of drug induced liver failure in the United States. Previous studies in our laboratory have shown that S-adenosyl methionine (SAMe) is protective for APAP hepatic toxicity. SAMe is critical for glutathione synthesis and transmethylation of nucleic acids, pro...

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Bibliografiske detaljer
Main Authors: Brown, J. Michael, Ball, John G., Hogsett, Amy, Williams, Tierra, Valentovic, Monica
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906679/
https://ncbi.nlm.nih.gov/pubmed/20450926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2010.04.018
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