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Temporal Study of Acetaminophen (APAP) and S-Adenosyl-L-methionine (SAMe) Effects on Subcellular Hepatic SAMe Levels and Methionine Adenosyltransferase (MAT) Expression and Activity
Acetaminophen (APAP) is the leading cause of drug induced liver failure in the United States. Previous studies in our laboratory have shown that S-adenosyl methionine (SAMe) is protective for APAP hepatic toxicity. SAMe is critical for glutathione synthesis and transmethylation of nucleic acids, pro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906679/ https://ncbi.nlm.nih.gov/pubmed/20450926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2010.04.018 |
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