S-Adenosyl-L-Methionine Protection of Acetaminophen Mediated Oxidative Stress and Identification of Hepatic 4-Hydroxynonenal Protein Adducts by Mass Spectrometry

Acetaminophen (APAP) hepatotoxicity is protected by S-adenosyl-L-methionine (SAMe) treatment 1 hour (h) after APAP in C57/Bl6 mice. This study examined protein carbonylation as well as mitochondrial and cytosolic protein adduction by 4-hydroxynonenal (4-HNE) using mass spectrometry (MS) analysis. Ad...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Brown, James Mike, Kuhlman, Christopher, Terneus, Marcus V., Labenski, Matthew T., Lamyaithong, Andre Benja, Ball, John G., Lau, Serrine S., Valentovic, Monica A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418180/
https://ncbi.nlm.nih.gov/pubmed/25246065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2014.08.027
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