Novel Protective Mechanisms for S-Adenosyl-L-methionine against Acetaminophen Hepatotoxicity: Improvement of Key Antioxidant Enzymatic Function

Acetaminophen (APAP) overdose leads to severe hepatotoxicity, increased oxidative stress and mitochondrial dysfunction. S-adenosyl-L-methionine (SAMe) protects against APAP toxicity at a mmol/kg equivalent dose to N-acetylcysteine (NAC). SAMe acts as a principle biological methyl donor and participa...

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Detalhes bibliográficos
Main Authors: Brown, J. Michael, Ball, John G., Wright, Michael Scott, Van Meter, Stephanie, Valentovic, Monica A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398222/
https://ncbi.nlm.nih.gov/pubmed/22683606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2012.05.018
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