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Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP

Native molten globules are the most folded kind of intrinsically disordered proteins. Little is known about the mechanism by which native molten globules bind to their cognate ligands to form fully folded complexes. The nuclear coactivator binding domain (NCBD) of CREB binding protein is particularl...

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Autors principals: Kjaergaard, Magnus, Teilum, Kaare, Poulsen, Flemming M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906600/
https://ncbi.nlm.nih.gov/pubmed/20616042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001693107
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