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Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration properties
Retroviral vectors offer benefits of efficient delivery and stable gene expression; however, their clinical use raises the concerns of insertional mutagenesis and potential oncogenesis due to genomic integration preferences in transcriptional start sites (TSS). We have shifted the integration prefer...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906550/ https://ncbi.nlm.nih.gov/pubmed/20616052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001402107 |
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