Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors

BACKGROUND: Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tumor. METHODS: Twenty-one paraffin-embedded bladder tumors were analyzed by co...

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Библиографические подробности
Главные авторы: del Rey, Javier, Prat, Esther, Ponsa, Immaculada, Lloreta, Josep, Gelabert, Antoni, Algaba, Ferran, Camps, Jordi, Miró, Rosa
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906479/
https://ncbi.nlm.nih.gov/pubmed/20540739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-280
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