Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors

BACKGROUND: Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tumor. METHODS: Twenty-one paraffin-embedded bladder tumors were analyzed by co...

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Hlavní autoři: del Rey, Javier, Prat, Esther, Ponsa, Immaculada, Lloreta, Josep, Gelabert, Antoni, Algaba, Ferran, Camps, Jordi, Miró, Rosa
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906479/
https://ncbi.nlm.nih.gov/pubmed/20540739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-280
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