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Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine
The accepted target for organophosphorus agent (OP) binding to enzymes is the active site serine in the consensus sequence Gly × Ser × Gly. New motifs have been identified by using mass spectrometry to fragment OP-labeled peptides. It has been found that OP can make covalent bonds with tyrosine and...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905678/ https://ncbi.nlm.nih.gov/pubmed/20211158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2010.03.002 |
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