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NMR solution structure of poliovirus uridylyated peptide linked to the genome (VPgpU)
Picornaviruses have a 22–24 amino acid peptide, VPg, bound covalently at the 5’ end of their RNA, that is essential for replication. VPgs are uridylylated at a conserved Tyrosine to form VPgpU, the primer of RNA synthesis by the viral polymerase. This first complete structure for any uridylylated VP...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905501/ https://ncbi.nlm.nih.gov/pubmed/20441784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2010.04.021 |
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