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Sequence specificity for uridylylation of the viral peptide linked to the genome (VPg) of enteroviruses

Enteroviruses (EV) uridylylate a peptide, VPg, as the first step in their replication. VPgpUpU, found free in infected cells, serves as the primer for RNA elongation. The abilities of four polymerases (3D(pol)), from EV-species A-C, to uridylylate VPgs that varied by up to 60% of their residues were...

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Publicat a:Virology
Autors principals: Schein, Catherine H., Ye, Mengyi, Paul, Aniko V., Oberste, M. Steven, Chapman, Nora, van der Heden van Noort, Gerbrand J., Filippov, Dmitri V., Choi, Kyung
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567471/
https://ncbi.nlm.nih.gov/pubmed/26074065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.05.016
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