Modification of picornavirus genomic RNA using ‘click’ chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA

Picornaviruses constitute a large group of viruses comprising medically and economically important pathogens such as poliovirus, coxsackievirus, rhinovirus, enterovirus 71 and foot-and-mouth disease virus. A unique characteristic of these viruses is the use of a viral peptide (VPg) as primer for vir...

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Detalhes bibliográficos
Main Authors: Langereis, Martijn A., Feng, Qian, Nelissen, Frank H. T., Virgen-Slane, Richard, van der Heden van Noort, Gerbrand J., Maciejewski, Sonia, Filippov, Dmitri V., Semler, Bert L., van Delft, Floris L., van Kuppeveld, Frank J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936719/
https://ncbi.nlm.nih.gov/pubmed/24243841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1162
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