Mouse Models for the p53 R72P Polymorphism Mimic Human Phenotypes

The p53 tumor suppressor gene contains a common single nucleotide polymorphism (SNP) that results in either an arginine or proline at position 72 of the p53 protein. This polymorphism affects the apoptotic activity of p53 but the mechanistic basis and physiological relevance of this phenotypic diffe...

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Autores principales: Zhu, Feng, Dollé, Martijn E.T., Berton, Thomas R., Kuiper, Raoul V., Capps, Carrie, Espejo, Alexsandra, McArthur, Mark J., Bedford, Mark T., van Steeg, Harry, de Vries, Annemieke, Johnson, David G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905499/
https://ncbi.nlm.nih.gov/pubmed/20587514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4646
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