Angiopoietin-2 interferes with anti-VEGFR2- induced vessel normalization and survival benefit in mice bearing gliomas

PURPOSE: In brain tumors, cerebral edema is a significant source of morbidity and mortality. Recent studies have shown that inhibition of VEGF signaling induces transient vascular normalization and reduces cerebral edema, resulting in a modest survival benefit in glioblastoma patients. During anti-V...

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Main Authors: Chae, Sung-Suk, Kamoun, Walid S., Farrar, Christian T., Kirkpatrick, Nathaniel D., Niemeyer, Elisabeth, de Graaf, Annemarie M.A., Sorensen, A. Gregory, Munn, Lance L., Jain, Rakesh K., Fukumura, Dai
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905497/
https://ncbi.nlm.nih.gov/pubmed/20501615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3073
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