PDGF-C Induces Maturation of Blood Vessels in a Model of Glioblastoma and Attenuates the Response to Anti-VEGF Treatment

BACKGROUND: Recent clinical trials of VEGF inhibitors have shown promise in the treatment of recurrent glioblastomas (GBM). However, the survival benefit is usually short-lived as tumors escape anti-VEGF therapies. Here we tested the hypothesis that Platelet Derived Growth Factor-C (PDGF-C), an isof...

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Detalhes bibliográficos
Main Authors: di Tomaso, Emmanuelle, London, Nyall, Fuja, Daniel, Logie, James, Tyrrell, James A., Kamoun, Walid, Munn, Lance L., Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662415/
https://ncbi.nlm.nih.gov/pubmed/19352490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005123
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