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Mutations in MTO2 Related to tRNA Modification Impair Mitochondrial Gene Expression and Protein Synthesis in the Presence of a Paromomycin Resistance Mutation in Mitochondrial 15 S rRNA
Nuclear gene(s) have been shown to modulate the phenotypic expression of mitochondrial DNA mutations. We report here the identification and characterization of the yeast nuclear gene MTO2 encoding an evolutionarily conserved protein involved in mitochondrial tRNA modification. Interestingly, mto2 nu...
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Κύριοι συγγραφείς: | , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
2005
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905382/ https://ncbi.nlm.nih.gov/pubmed/15944150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M504247200 |
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