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Mutations in MTO2 Related to tRNA Modification Impair Mitochondrial Gene Expression and Protein Synthesis in the Presence of a Paromomycin Resistance Mutation in Mitochondrial 15 S rRNA

Nuclear gene(s) have been shown to modulate the phenotypic expression of mitochondrial DNA mutations. We report here the identification and characterization of the yeast nuclear gene MTO2 encoding an evolutionarily conserved protein involved in mitochondrial tRNA modification. Interestingly, mto2 nu...

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Sonraí Bibleagrafaíochta
Main Authors: Yan, Qingfeng, Li, Xiaoming, Faye, Gèrard, Guan, Min-Xin
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905382/
https://ncbi.nlm.nih.gov/pubmed/15944150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M504247200
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