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Topoisomerase I regulates open chromatin and controls gene expression in vivo

DNA topoisomerases regulate the topological state of the DNA double helix and are key enzymes in the processes of DNA replication, transcription and genome stability. Using the fission yeast model Schizosaccharomyces pombe, we investigate genome wide how DNA topoisomerases I and II affect chromatin...

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Autors principals: Durand-Dubief, Mickaël, Persson, Jenna, Norman, Ulrika, Hartsuiker, Edgar, Ekwall, Karl
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905247/
https://ncbi.nlm.nih.gov/pubmed/20526281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.109
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