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The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing

The essential RNA helicase, Mtr4, performs a critical role in RNA processing and degradation as an activator of the nuclear exosome. The molecular basis for this vital function is not understood and detailed analysis is significantly limited by the lack of structural data. In this study, we present...

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Autors principals: Jackson, Ryan N, Klauer, A Alejandra, Hintze, Bradley J, Robinson, Howard, van Hoof, Ambro, Johnson, Sean J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905245/
https://ncbi.nlm.nih.gov/pubmed/20512111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.107
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