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Aggregation of deamidated human βB2-crystallin and incomplete rescue by α-crystallin chaperone

Aging of the lens is accompanied by extensive deamidation of the lens specific proteins, the crystallins. Deamidated crystallins are increased in the insoluble proteins and may contribute to cataracts. Deamidation has been shown in vitro to alter the structure and decrease the stability of human len...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Michiel, Magalie, Duprat, Elodie, Skouri-Panet, Fériel, Finet, Stéphanie, Tardieu, Annette, Lampi, Kirsten J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904749/
https://ncbi.nlm.nih.gov/pubmed/20188088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2010.02.007
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