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DCB-3503, a Tylophorine Analog, Inhibits Protein Synthesis through a Novel Mechanism

BACKGROUND: DCB-3503, a tylophorine analog, inhibits the growth of PANC-1 (human pancreatic ductal cancer cell line) and HepG2 (human hepatocellular cancer cell line) tumor xenografts in nude mice. The inhibition of growth leads to cancer cell differentiation instead of cell death. However, the mech...

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Autori principali: Wang, Ying, Gao, Wenli, Svitkin, Yuri V., Chen, Annie Pei-Chun, Cheng, Yung-Chi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904705/
https://ncbi.nlm.nih.gov/pubmed/20657652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011607
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