Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication

Tylophorine analogs have been shown to exhibit diverse activities against cancer, inflammation, arthritis, and lupus in vivo. In this study, we demonstrated that two tylophorine analogs, DCB-3503 and rac-cryptopleurine, exhibit potent inhibitory activity against hepatitis C virus (HCV) replication i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wang, Ying, Lee, Sangwon, Ha, Ya, Lam, Wing, Chen, Shao-Ru, Dutschman, Ginger E., Gullen, Elizabeth A., Grill, Susan P., Cheng, Yao, Fürstner, Alois, Francis, Samson, Baker, David C., Yang, Xiaoming, Lee, Kuo-Hsiung, Cheng, Yung-Chi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577180/
https://ncbi.nlm.nih.gov/pubmed/28855547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08815-z
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