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DCB-3503, a Tylophorine Analog, Inhibits Protein Synthesis through a Novel Mechanism

BACKGROUND: DCB-3503, a tylophorine analog, inhibits the growth of PANC-1 (human pancreatic ductal cancer cell line) and HepG2 (human hepatocellular cancer cell line) tumor xenografts in nude mice. The inhibition of growth leads to cancer cell differentiation instead of cell death. However, the mech...

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Detalhes bibliográficos
Main Authors: Wang, Ying, Gao, Wenli, Svitkin, Yuri V., Chen, Annie Pei-Chun, Cheng, Yung-Chi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904705/
https://ncbi.nlm.nih.gov/pubmed/20657652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011607
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