Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells

Commensal microbes can have a substantial impact on autoimmune disorders, but the underlying molecular and cellular mechanisms remain largely unexplored. We report that autoimmune arthritis was strongly attenuated in the K/BxN mouse model under germ-free (GF) conditions, accompanied by reductions in...

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Hauptverfasser: Wu, Hsin-Jung, Ivanov, Ivaylo I., Darce, Jaime, Hattori, Kimie, Shima, Tatsuichiro, Umesaki, Yoshinori, Littman, Dan R., Benoist, Christophe, Mathis, Diane
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904693/
https://ncbi.nlm.nih.gov/pubmed/20620945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.06.001
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