Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection

GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme for tetrahydrobiopterin (BH(4)) synthesis. Decreases in GTPCH activity and expression have been shown in late stages of acute cardiac rejection, suggesting a deficit in BH(4). We hypothesized that increasing intracellular levels of BH(4) by ca...

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Detalhes bibliográficos
Main Authors: Ionova, Irina A., Vásquez-Vivar, Jeannette, Cooley, Brian C., Khanna, Ashwani K., Whitsett, Jennifer, Herrnreiter, Anja, Migrino, Raymond Q., Ge, Zhi-Dong, Regner, Kevin R., Channon, Keith M., Alp, Nicholas J., Pieper, Galen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904123/
https://ncbi.nlm.nih.gov/pubmed/20418482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00203.2010
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