Sepiapterin Decreases Acute Rejection and Apoptosis in Cardiac Transplants Independently of Changes in Nitric Oxide and Inducible Nitric-Oxide Synthase Dimerization

Tetrahydrobiopterin (BH(4)), a cofactor of inducible nitric-oxide synthase (iNOS), is an important post-translational regulator of NO bioactivity. We examined whether treatment of cardiac allograft recipients with sepiapterin [S-(-)-2-amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4-(1H)-pteridinone],...

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Detalhes bibliográficos
Main Authors: Pieper, Galen M., Ionova, Irina A., Cooley, Brian C., Migrino, Raymond Q., Khanna, Ashwani K., Whitsett, Jennifer, Vásquez-Vivar, Jeannette
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683770/
https://ncbi.nlm.nih.gov/pubmed/19307452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.148569
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