Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression

Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes and renal proximal tubule epithelium. MRP4/Mrp4 undergoes adaptive upregulation in response to oxidative and cholest...

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Main Authors: Xu, Shuhua, Weerachayaphorn, Jittima, Cai, Shi-Ying, Soroka, Carol J., Boyer, James L.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
Assuntos:
Liver and Biliary Tract
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904108/
https://ncbi.nlm.nih.gov/pubmed/20395535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00522.2010
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