Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

Benzer Materyaller

• A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases
  Yazar:: Kathman, Stefan G., ve diğerleri
  Baskı/Yayın Bilgisi: (2014)
• Mechanism of Carbamate Inactivation of FAAH: Implications for the Design of Covalent Inhibitors and In Vivo Functional Probes for Enzymes
  Yazar:: Alexander, Jessica P., ve diğerleri
  Baskı/Yayın Bilgisi: (2005)
• Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1
  Yazar:: Bachovchin, Daniel A., ve diğerleri
  Baskı/Yayın Bilgisi: (2011)
• Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling
  Yazar:: Suciu, Radu M., ve diğerleri
  Baskı/Yayın Bilgisi: (2018)
• (P2) Activity-Based Proteomics–Applications for Enzyme and Inhibitor Discovery
  Yazar:: Cravatt, Benjamin F.
  Baskı/Yayın Bilgisi: (2013)