Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

Lignende værker

• A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases
  af: Kathman, Stefan G., et al.
  Udgivet: (2014)
• Mechanism of Carbamate Inactivation of FAAH: Implications for the Design of Covalent Inhibitors and In Vivo Functional Probes for Enzymes
  af: Alexander, Jessica P., et al.
  Udgivet: (2005)
• Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1
  af: Bachovchin, Daniel A., et al.
  Udgivet: (2011)
• Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling
  af: Suciu, Radu M., et al.
  Udgivet: (2018)
• (P2) Activity-Based Proteomics–Applications for Enzyme and Inhibitor Discovery
  af: Cravatt, Benjamin F.
  Udgivet: (2013)