Protection of Pancreatic β-Cells by Group VIA Phospholipase A(2)-Mediated Repair of Mitochondrial Membrane Peroxidation

Mitochondrial production of reactive oxygen species and oxidation of cardiolipin are key events in initiating apoptosis. We reported that group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)β) localizes in and protects β-cell mitochondria from oxidative damage during staurosporine-induced apopto...

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Autores principales: Zhao, Zhengshan, Zhang, Xu, Zhao, Chunying, Choi, Jinwoo, Shi, Jieyi, Song, Keying, Turk, John, Ma, Zhongmin Alex
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903934/
https://ncbi.nlm.nih.gov/pubmed/20463052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0016
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